The Effect of Coffee Arabica (Coffea arabica L.) Fruit Skin Extracts on Small Intestine Morphometry of mice (Mus musculus L.) with Ethanol-Induced

Consumption of alcoholic beverages can increase ROS and inflammation. In the duodenal, consumption alcohol result in erosions, bleeding, mucosal injury. Arabica coffee fruit skin contains antioxidant substances, which are expected to have a good role as an effect. Currently, unknown effects extract administration on damage small intestine mice (Mus musculus L.). This study used experimental design, 25 males were divided into five groups treatment for 15 days. After treatment, at necropsied taken histopathological examination using hematoxyline-eosin staining. The Data analyzed One Way ANOVA Duncan's tests. Histopathological observations showed dose 250 mg/kg BW experienced most significant improvement compared other treatments. Histomorphometry measurement, BB high villi 272,10 ± 13,36 µm, (P<0.05), duodenal crypt depth 117,33 30,35 µm (P<0.05) surface area intestinal 7,66 0,55 mm 2 was similar with negative control. conclusion this is able improve histopathology morphometry that damaged due ethanol 15%.